A Meta-Analysis of the Impact of Lifestyle and Gynecologic Oncology Nursing Interventions on the Enhancement of Quality of Life.

This meta-analysis evaluated the impact of lifestyle and gynecologic oncology nursing interventions on quality of life (QoL). A systematic search conducted through June 2026 identified 1,123 records. Thirteen randomized controlled trials involving 915 women with gynecologic cancer were included. The impact of lifestyle and gynecologic oncology nursing interventions on QoL was evaluated using pooled mean differences (MDs) with 95% confidence intervals, using random-effects models for the general analyses and fixed-effect models for the cancer-specific subgroup analyses. Compared with controls, interventions significantly improved QoL in women with ovarian cancer (MD 4.28, 95% CI: 0.45-8.10, p = 0.03; I2 = 0%). No significant differences emerged for 6-month QoL in mixed cancers (MD 2.11, 95% CI: -0.90-5.12, p = 0.17; I2 = 71%), endometrial cancer at 6 months (MD 2.00, 95% CI: -1.49-5.49, p = 0.26; I2 = 0%) or mixed cancers at 3 months (MD 6.43, 95% CI: -0.16-13.01, p = 0.06; I2 = 74%). However, marked heterogeneity, varied designs and interventions, small sample sizes, and variable risk of bias limit the certainty of the findings, which warrant cautious interpretation and confirmation through robust, standardized trials. Lifestyle and gynecologic oncology nursing interventions significantly improved QoL only in women with ovarian cancer at 6 months. However, substantial heterogeneity, methodological limitations, and very low-certainty evidence warrant cautious interpretation, and larger standardized trials are needed.